HYPOTHYROIDISM AND ARTHRITIS DURING INTERFERON THERAPY

被引:14
作者
DHONDT, L [1 ]
DELANNOY, A [1 ]
DOCQUIER, C [1 ]
机构
[1] HOP JOLIMONT,SERV MED INTERNE,B-7100 HAINE ST PAUL,BELGIUM
关键词
ALPHA-INTERFERON; CHRONIC MYELOCYTIC LEUKEMIA; AUTOIMMUNE THYROIDITIS;
D O I
10.1007/BF02231591
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The development of autoantibodies during interferon therapy is frequent, but clinical symptoms of autoimmune disease are uncommon. We report on a female patient who developed arthritis with strongly positive antinuclear factor (ANA) and autoimmune thyroiditis while being treated with alpha 2b interferon (IFN) for chronic myelocytic leukaemia (CML). The arthritis subsided promptly after discontinuation of IFN and initiation of nonsteroidal anti-inflammatory drugs.
引用
收藏
页码:415 / 417
页数:3
相关论文
共 12 条
[1]  
Quesada J.R., Talpaz M., Rios A., Kurzrock R., Gutterman J., Clinical toxicity of interferons in cancer patients: a review, J Clin Oncol, 4, pp. 234-243, (1986)
[2]  
Fentiman J.S., Thomas B.S., Balkwill F.R., Rubens R.D., Hayward J.L., Primary hypothyroidism associated with interferon therapy of breast cancer, Lancet, 1, (1985)
[3]  
Akard L.P., Hoffman R., Elias L., Saiers J.H., Alpha-interferon and immune hemolytic anemia, Ann Intern Med, 105, (1986)
[4]  
Abdi E.A., Venner P.M., Immune thrombocytopenia after alpha-interferon therapy in patients with cancer, JAMA, 255, pp. 1878-1879, (1986)
[5]  
Mangan K.F., Zidar B., Shadduck R.K., Zeigler Z., Winkelstein A., Interferon-induced aplasia: Evidence for T-cell mediated suppression of hematopoiesis and recovery after treatment with horse antihuman thymocyte globulin, Am J Hematol, 19, pp. 401-413, (1985)
[6]  
Conlon K.C., Urba W.J., Smith J.W., Steis R.G., Longo D.L., Clark J.W., Exacerbation of symptoms of autoimmune disease in patients receiving alpha-interferon therapy, Cancer, 65, pp. 2237-2242, (1990)
[7]  
Schilling P.J., Kurzrock R., Kantarjian H., Gutterman J.U., Talpaz M., Development of systemic lupus erythematosus after interferon therapy for chronic myelogenous leukemia, Cancer, 68, pp. 1536-1537, (1991)
[8]  
Ronnblom L.E., Gunnar V.A., Kjell E.O., Autoimmunity after alpha-interferon therapy for malignant carcinoid tumors, Annals of Internal Medicine, 115, pp. 178-183, (1991)
[9]  
Chazerain P., Meyer O., Kahn M.F., Rheumatoid arthritis-like disease after alpha-interferon therapy, Ann Intern Med, 116, (1992)
[10]  
Ueno Y., Sohma T., Alpha-interferon-induced nodular rheumatoid arthritis in renal cell carcinoma, Ann Intern Med, 117, pp. 266-267, (1992)