SOLUBILITY OF PARABENS IN ALCOHOLS

被引：20

作者：

PARUTA, AN

机构：

[1] College of Pharmacy, University of Rhode Island, Kingston, Rhode Island

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 02期

关键词：

1‐Alkanols; carbon number—paraben solubility; Dielectric constants; 1‐alkanols—paraben solubility; Parabens solubility—alcohols; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600580216

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The solubilities of methyl, ethyl, propyl, and butyl parabens have been determined in a series of normal alcohols. This pure solvent scan indicated a dielectric requirement of about 14 for the subject compounds. Another dielectric requirement may be postulated to exist at a value of about 30. There is seen to be good parallelism in the magnitude of solubility of these compounds in various 1‐alkanols indicating interactions of a similar nature in the dissolution process. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：216 / &

共 7 条

[1]

BURRELL H, 1955, INTERCHEM REV, V14, P3

[2] The use of chemical potentials as indices of toxicity [J].