CORRELATION OF SCD23 RELEASE AND IMMUNOGLOBULIN (E, A, G, M) SYNTHESIS BY PERIPHERAL-BLOOD LYMPHOCYTES OF ATOPIC PATIENTS

Peripheral blood lymphocytes of atopic patients were analyzed with regard to spontaneous as well as mitogen-induced CD23 expression, sCD23 release as well as Ig (M, G, A, E) synthesis in vitro. The data were correlated with the results for phenotypically defined peripheral cells (T cells, B cells, monocytes), sCD23 release and amounts of Ig (M, G, A, E). A positive correlation was obtained for serum sCD23 and serum IgE of patients with high and intermediate IgE levels, of sCD23 with the percentage of B cells and sCD23 with serum IgA levels. No correlation was obtained for the mitogen (SAC, PWM) induced amounts of Ig (E, A, M, G) synthesis and, furthermore, sCD23 levels determined in cell culture did not correlate with serum IgE levels. Our data support the role of sCD23 in atopic diseases and in isotype regulation. © 1990 S. Karger AG, Basel.