NONUNIFORM INFLUENCE OF TRANSFORMING GROWTH-FACTOR-BETA ON THE BIOSYNTHESIS OF DIFFERENT FORMS OF SMALL CHONDROITIN SULFATE DERMATAN SULFATE PROTEOGLYCAN

被引：73

作者：

BREUER, B ^{[1
]}

SCHMIDT, G ^{[1
]}

KRESSE, H ^{[1
]}

机构：

[1] UNIV MUNSTER,INST PHYSIOL CHEM & PATHOBIOCHEM,WALDEYERSTR 15,W-4400 MUNSTER,GERMANY

来源：

BIOCHEMICAL JOURNAL | 1990年 / 269卷 / 02期

关键词：

D O I：

10.1042/bj2690551

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of transforming growth factor-β (TGF-β) on the expression of different forms of small proteoglycans was investigated in human skin fibroblasts and in a human osteosarcoma cell line. TGF-β was not found to act as a general stimulator of small proteoglycan biosynthesis. In both cell types, an increased expression of the core protein of proteoglycan I was found. However, there was a profound decrease in the expression of a 106 kDa core protein, and either no alteration or a small decrease in the biosynthesis of the collagen-binding small proteoglycan II core protein. These results show that the production of individual members of the small proteoglycan family is differentially regulated.

引用

页码：551 / 554

页数：4

共 27 条

[1] TRANSFORMING GROWTH FACTOR-BETA INCREASES CELL-SURFACE BINDING AND ASSEMBLY OF EXOGENOUS (PLASMA) FIBRONECTIN BY NORMAL HUMAN-FIBROBLASTS [J].

ALLENHOFFMANN, BL ;

CRANKSHAW, CL ;

MOSHER, DF .

MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (10) :4234-4242

[2]

ASSOIAN RK, 1983, J BIOL CHEM, V258, P7155

[3]

BASSOLS A, 1988, J BIOL CHEM, V263, P3039

[4]

CHEIFETZ S, 1989, J BIOL CHEM, V264, P12025

[5] TRANSFORMING GROWTH-FACTOR TYPE-BETA SPECIFICALLY STIMULATES SYNTHESIS OF PROTEOGLYCAN IN HUMAN ADULT ARTERIAL SMOOTH-MUSCLE CELLS [J].

CHEN, JK ;

HOSHI, H ;

MCKEEHAN, WL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (15) :5287-5291

[6]

FISHER LW, 1989, J BIOL CHEM, V264, P4571

[7]

GLOSSL J, 1984, J BIOL CHEM, V259, P4144

[8]

GREVE H, 1988, J BIOL CHEM, V263, P12886

[9]

HEDBOM E, 1989, J BIOL CHEM, V264, P6898

[10]

IGNOTZ RA, 1986, J BIOL CHEM, V261, P4337

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