PARADOXICAL EFFECTS OF 5-FU FOLINIC ACID ON LYMPHOKINE-ACTIVATED KILLER (LAK) CELL INDUCTION IN PATIENTS WITH COLORECTAL-CANCER

被引：12

作者：

ONODERA, H ^{[1
]}

SOMERS, SS ^{[1
]}

GUILLOU, PJ ^{[1
]}

机构：

[1] ST MARYS HOSP,SCH MED,ACAD SURG UNIT,QUEEN ELIZABETH QUEEN MOTHER WING,LONDON W2 1NY,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1990年 / 62卷 / 06期

关键词：

D O I：

10.1038/bjc.1990.436

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of treatment with 5-FU/folinic acid on interleukin-2 related lymphocyte responses was investigated in 21 patients with advanced colorectal cancer. The treatment was not suppressive of IL-2 related lymphocyte responses. Furthermore, at certain time points in the treatment cycles the capacity to generate lymphokine-activated killer (LAK) cells from the peripheral blood mononuclear cells of these patients was significantly augmented above that observed prior to treatment. These results provide a logical basis for the design of regimens which combine two approaches, each of low individual therapeutic efficacy, to treat patients with advanced colorectal cancer in the hope of increasing clinical response rates. © Macmillan Press Ltd., 1990.

引用

页码：1042 / 1046

页数：5

共 32 条

[1]

ADES EW, 1987, NAT IMMUN CELL GROW, V6, P260

[2]

ARBUCK SG, 1989, CANCER, V63, P1036, DOI 10.1002/1097-0142(19890315)63:6+<1036::AID-CNCR2820631309>3.0.CO

[3]

2-K

[4]

ARINAGA S, 1986, CANCER RES, V46, P4213

[5]

BOLDT DH, 1988, CANCER RES, V48, P4409

[6] A T-CELL RECEPTOR GAMMA-CD3 COMPLEX FOUND ON CLONED FUNCTIONAL LYMPHOCYTES [J].

BORST, J ;

VANDEGRIEND, RJ ;

VANOOSTVEEN, JW ;

ANG, SL ;

MELIEF, CJ ;

SEIDMAN, JG ;

BOLHUIS, RLH .

NATURE, 1987, 325 (6106) :683-688

[7]

DOROSHOW JH, 1987, NATL CANCER I MONOGR, V5, P171

[8] EFFICACY OF CHEMO-IMMUNOTHERAPY WITH CYCLOPHOSPHAMIDE, INTERLEUKIN-2 AND LYMPHOKINE ACTIVATED KILLER CELLS IN AN INTRAPERITONEAL MURINE TUMOR-MODEL [J].

EGGERMONT, AMM ;

SUGARBAKER, PH .

BRITISH JOURNAL OF CANCER, 1988, 58 (04) :410-414

[9] A RANDOMIZED TRIAL OF FLUOROURACIL AND FOLINIC ACID IN PATIENTS WITH METASTATIC COLORECTAL-CARCINOMA [J].

ERLICHMAN, C ;

FINE, S ;

WONG, A ;

ELHAKIM, T .

JOURNAL OF CLINICAL ONCOLOGY, 1988, 6 (03) :469-475

[10] THE COMBINATION OF RECOMBINANT INTERLEUKIN-2 AND DACARBAZINE (DTIC) IN METASTATIC MALIGNANT-MELANOMA [J].

FLAHERTY, L .

CANCER TREATMENT REVIEWS, 1989, 16 :65-66

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