AGE-DEPENDENT VARIATIONS OF LYSOSOMAL ENZYMES IN HUMAN-LIVER

被引：5

作者：

MINAMI, R

SATO, S

KUDOH, T

OYANAGI, K

NAKAO, T

机构：

[1] Department of Pediatrics, Sapporo Medical College

来源：

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE | 1979年 / 129卷 / 01期

关键词：

D O I：

10.1620/tjem.129.65

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The specific activities, the Km values, and the elution patterns on DEAE 52 and Sephadex G-150 columns of 6 lysosomal enzymes in human liver during development were studied. The levels of total .beta.-D-glucuronidase and N-acetyl-.beta.-D-glucosaminidase activities in childhood liver were higher than those in fetal liver. The Km values of .beta.-D-glucuronidase and .beta.-D-galactosidase in fetal liver were about 10 times higher than those in childhood liver. The elution patterns on DEAE 52 of .beta.-D-glucuronidase and on Sephadex G-150 of .alpha.-D- and .beta.-D-galactosidases changed with aging. Lysosomal enzymes related to degradation of gangliosides and glycosaminoglycans may change during development.

引用

页码：65 / 70

页数：6

共 9 条

[1] ISOENZYME PATTERNS OF HUMAN LIVER ALPHA-L-FUCOSIDASE DURING DEVELOPMENT [J].