ISOLATION AND CHARACTERIZATION OF A NOVEL CDNA CLONE ENCODING A HOMEODOMAIN THAT IS DEVELOPMENTALLY REGULATED IN THE VENTRAL FOREBRAIN

被引：209

作者：

PORTEUS, MH ^{[1
]}

BULFONE, A ^{[1
]}

CIARANELLO, RD ^{[1
]}

RUBENSTEIN, JLR ^{[1
]}

机构：

[1] STANFORD UNIV, MED CTR,SCH MED,DEPT PSYCHIAT & BEHAV SCI, NANCY PRITZKER DEV & MOLEC NEUROBIOL LAB, STANFORD, CA 94305 USA

来源：

NEURON | 1991年 / 7卷 / 02期

关键词：

D O I：

10.1016/0896-6273(91)90260-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A complementary DNA, Tes-1, of a novel homeodomain protein has been cloned, and its pattern of expression has been characterized. It is a structural homolog of Distal-less, a homeodomain-encoding gene in D. melanogaster. Its expression is developmentally regulated and is limited to structures in the head. Within the central nervous system of the midgestation mouse embryo, it is expressed exclusively in the ventral forebrain. It is likely that Tes-1 plays a regulatory role in the development of this complex neural structure.

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页码：221 / 229

页数：9

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