EXTREMELY POOR PROGNOSIS OF PEDIATRIC ACUTE LYMPHOBLASTIC-LEUKEMIA WITH TRANSLOCATION (9 22) - UPDATED EXPERIENCE

被引：12

作者：

FLETCHER, JA

TU, N

TANTRAVAHI, R

SALLAN, SE

机构：

[1] Department of Pediatric Oncology and Divisions of Biostatistics and Cytogenetics, Dana-Farber Cancer Institute, Boston, MA

[2] Division of Hematology/Oncology, Children's Hospital, Boston, MA

[3] Department of Pathology, Brigham and Women's Hospital, Boston, MA

[4] Departments of Pediatrics and Pathology, Harvard Medical School, Boston, MA

来源：

LEUKEMIA & LYMPHOMA | 1992年 / 8卷 / 1-2期

关键词：

ALL; ACUTE LEUKEMIA; POOR PROGNOSIS ALL; T(9 22) PEDIATRIC LEUKEMIA;

D O I：

10.3109/10428199209049820

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Approximately five percent of pediatric acute lymphoblastic leukemias (ALL) contain a translocation (9;22)(q34;q11) which results in rearrangement of the bcr and abl genes. At a median follow-up of 5 years, we assessed the prognostic implications of translocation (9;22) in 434 children receiving intensive treatment for ALL. Four-year event-free and overall survivals were only 0% and 20%, respectively, in 15 children with translocation (9;22), but were 81 % and 89%, respectively, in 419 children lacking translocation (9;22) (P < 0.00 1). Based on these findings, we recommend very intensive treatment approaches for all children with translocation (9;22)-positive ALL.

引用

页码：75 / 79

页数：5

共 37 条

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