THYROTROPIN RESPONSE TO THYROTROPIN-RELEASING-HORMONE IN PATIENTS WITH DEMENTIA OF THE ALZHEIMER TYPE

被引：11

作者：

ALBERT, M

JENIKE, M

NIXON, R

NOBEL, K

机构：

[1] HEBREW REHABIL CTR AGED,BOSTON,MA

[2] MASSACHUSETTS GEN HOSP,DEPT PSYCHIAT & NEUROL,BOSTON,MA 02114

[3] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[4] MCLEAN HOSP,BELMONT,MA 02178

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 04期

关键词：

TRH; ALZHEIMERS DISEASE; DEPRESSION;

D O I：

10.1016/0006-3223(93)90293-M

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Eleven patients with senile dementia of the Alzheimer type and 11 age-matched control subjects were given the thyrotropin-releasing hormone (TRH) test. The two groups did not differ with respect to peak thyrotropin (TSH) response or TSH levels at baseline, 20, 30, and 45 min after TRH injection. There were significant differences between the groups on Hamilton Depression Rating Scale scores (p < 0.03), although neither group met clinical criteria for depression. Items that were significantly different pertained to depressed mood, loss of interest, loss of insight, suicidal ideation, and obsessional symptoms.

引用

页码：267 / 271

页数：5

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