COMPARISON OF THE EFFICACY OF AZT AND PMEA TREATMENT AGAINST ACUTE SIV(MNE) INFECTION IN MACAQUES

被引：24

作者：

TSAI, CC

FOLLIS, KE

GRANT, R

SABO, A

NOLTE, R

BARTZ, C

BISCHOFBERGER, N

BENVENISTE, R

机构：

[1] GILEAD SCI,FOSTER CITY,CA

[2] NCI,FREDERICK,MD 21701

来源：

JOURNAL OF MEDICAL PRIMATOLOGY | 1994年 / 23卷 / 2-3期

关键词：

ANTIVIRAL DRUGS; MONKEYS; SIV; HIV;

D O I：

10.1111/j.1600-0684.1994.tb00119.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The antiretroviral drugs azidothymidine (AZT) and 9-(-2-phosphonyl-methoxyethyl)adenine (PMEA) were individually tested for prevention of simian immunodeficiency ViruS (SIV(mne)) infection in macaques (Macaca fascicularis). Macaques were pretreated with either drug before inoculation with SIV(mne), and drug treatment was continued for four weeks. The virus, antibody, and clinical status of the macaques was monitored for up to 36 weeks following inoculation. While AZT prophylaxis resulted in reduced virus load in some macaques, PMEA prophylaxis was highly efficacious in preventing acute SIV(mne) infection.

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页码：175 / 183

页数：9

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