INTERFERON FOR CHRONIC HEPATITIS-C IN PATIENTS CURED OF MALIGNANCY

被引：11

作者：

CESARO, S

ROSSETTI, F

DEMOLINER, L

CRIVELLARO, C

ZANESCO, L

BORTOLOTTI, E

机构：

[1] UNIV PADUA,DIV INTERNAL MED 2,I-35128 PADUA,ITALY

[2] OSPED CIVILE,DIV INFECT DIS,I-35128 PADUA,ITALY

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1994年 / 153卷 / 09期

关键词：

CHRONIC HEPATITIS; HEPATITIS C VIRUS; CHILDHOOD MALIGNANCY; RECOMBINANT INTERFERON-ALPHA;

D O I：

10.1007/s004310050208

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Six patients with chronic hepatitis C who were cured of malignancy were treated with recombinant interferon-alpha at the dose of 4 MU/m(2) for 12 months; the post-treatment follow up period was 12 months. Therapy was stopped within 6 months in three patients because of persistently abnormal alanine aminotransferase levels. In the remaining three patients, a complete normalization of alanine aminotransferase levels was obtained during treatment but it was not maintained after the end of interferon therapy. In addition, no patient cleared hepatitis C virus ribonucleic acid in serum. These results suggest that recombinant interferon is not effective in patients with chronic hepatitis C who were cured of a previous malignancy.

引用

页码：659 / 662

页数：4

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