EFFECT OF ELECTROLYTES ON PHOSPHOLIPID-STABILIZED SOYBEAN OIL-EMULSIONS

被引：42

作者：

DAWES, WH

GROVES, MJ

机构：

[1] Department of Pharmacy, Chelsea College (University of London), London, SW3 6LX England, Manresa Road

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1978年 / 1卷 / 03期

关键词：

D O I：

10.1016/0378-5173(78)90016-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The properties of the droplets of a commercial phospholipid-:stabilized soyabean oil emulsion, Intralipid 10%, have been investigated by laser centrifugal photosedimentometer (LCP) and Zeta Meter. The surface charge is readily affected by added electrolytes and in the presence of physiological saline is reduced to zero. This may account for the anomalous sedimentation behaviour previously observed for Intralipid emulsions and confirmed here for sodium and calcium chlorides. The effects produced by cations may be related to their valency but anions are broadly similar to each other. Differences observed in behaviour may be due to different degrees of binding of the cations on the phospholipid interface. © 1978.

引用

页码：141 / 150

页数：10

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