OLIGOCLONAL IMMUNOGLOBULINS AND PLASMA-CELLS IN SPINAL-FLUID OF PATIENTS WITH MULTIPLE-SCLEROSIS

被引：100

作者：

THOMPSON, EJ ^{[1
]}

KAUFMANN, P ^{[1
]}

SHORTMAN, RC ^{[1
]}

RUDGE, P ^{[1
]}

MCDONALD, WI ^{[1
]}

机构：

[1] NATL HOSP,LONDON WC1N 3BG,ENGLAND

来源：

BRITISH MEDICAL JOURNAL | 1979年 / 1卷 / 6155期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1136/bmj.1.6155.16

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A new modification of polyacrylamide gel electrophoresis (PAGE) was applied to cerebrospinal fluid proteins from patients with multiple sclerosis (MS). The same spinal fluids were also examined by a cytological technique. Over 90% of patients with clinically definite or early probable or latent MS showed abnormal PAGE patterns in the form of oligoclonal gammaglobulin bands. Reactive (atypical, large) lymphocytes or typical plasma cells were found in some patients. In all such cases an oligoclonal pattern was present. The finding of oligoclonal bands provides valuable supporting evidence for the diagnosis of MS in the less definite clinical categories. © 1979, British Medical Journal Publishing Group. All rights reserved.

引用

页码：16 / 17

页数：2

共 18 条

[1]

CERVOS-NAVARRO J, 1959, Dtsch Z Nervenheilkd, V179, P614

[2]

COHEN S, 1967, LANCET, V1, P366

[3] FACTORS INFLUENCING RISK OF MULTIPLE-SCLEROSIS DEVELOPING IN PATIENTS WITH OPTIC NEURITIS [J].