LOSS OF DENDRITIC SYNAPSES IN THE MEDIAL AMYGDALA ASSOCIATED WITH KINDLING

被引：23

作者：

NISHIZUKA, M ^{[1
]}

OKADA, R ^{[1
]}

SEKI, K ^{[1
]}

ARAI, Y ^{[1
]}

IIZUKA, R ^{[1
]}

机构：

[1] JUNTENDO UNIV,SCH MED,DEPT PSYCHIAT,TOKYO 113,JAPAN

来源：

BRAIN RESEARCH | 1991年 / 552卷 / 02期

关键词：

KINDLING; AMYGDALA; DENDRITIC SYNAPSE; REMODELING;

D O I：

10.1016/0006-8993(91)90104-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Kindling stimulation was given in the basolateral amygdala (BLA), the septal area or the corpus callosum in the right hemisphere of adult rats. The density of dendritic synapses was electron microscopically studied in the medial amygdaloid nucleus (MAN) ipsi- and contralateral to the stimulation side. The number of dendritic synapses was markedly decreased in both sides of the MAN of 3 groups of kindled rats. Such reduction occurred in both dendritic shaft and spine synapses. The most remarkable decrease was obtained in the BLA kindling. These results suggest that a decrease of synapses may provide a morphological basis for kindling.

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页码：351 / 355

页数：5

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