DELAYED MITOGENIC RESPONSES TO PHYTOHEMAGGLUTININ IN ACUTE LYMPHOBLASTIC LEUKEMIA

被引：4

作者：

FAIRCHILD, SS ^{[1
]}

COHEN, JJ ^{[1
]}

机构：

[1] UNIV ALABAMA,SCH MED,WALLACE TUMOR INST,BIRMINGHAM,AL 35294

来源：

LEUKEMIA RESEARCH | 1979年 / 3卷 / 03期

关键词：

D O I：

10.1016/0145-2126(79)90014-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peripheral blood mononuclear cells from seven children with acute lymphoblastic leukemia (ALL) had, delayed responses to the T cell mitogen phytohemagglutinin (PHA) in vitro. Furthermore, responses were usually lower than those of normal peripheral cells. Neither the magnitude nor the time of peak response to mitogen could be correlated with the peripheral white cell count or the absolute number of T lymphocytes in these patients. The cells which responded to PHA formed rosettes with sheep red blood cells, and could be removed by exploiting this property. Furthermore, they had a normal karyotype in patients whose leukemia cells were aneuploid. Therefore, a small number of residual normal T cells is responsible for the late response to PHA in ALL. © 1979.

引用

页码：163 / 169

页数：7

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