POSSIBLE ALPHA-ADRENERGIC MECHANISM FOR DRUG (CRL40028)-INDUCED HYPERACTIVITY

被引：45

作者：

DUTEIL, J

RAMBERT, FA

PESSONNIER, J

GOMBERT, R

ASSOUS, E

机构：

[1] Centre de Recherches, Laboratoire L. Lafon, 94701 Maisons-Alfort, 1, Rue George Mederic

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 1-2期

关键词：

Mice; Motor activity; α; Blockers; α-Noradrenergic receptor stimulation;

D O I：

10.1016/0014-2999(79)90033-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

CRL 40028 (benzhydryl sulfinyl acetohydroxamic acid)-induced stimulation in mice, measured as an increase in locomotor activity was studied following an intraperitoneal injection of drugs known to block α-adrenergic receptors. Phenoxybenzamine (20 mg/kg), prazosin (0.5-1 mg/kg) and yohimbine (2 mg/kg) prevented the development of CRL 40028-induced hyperactivity. These results suggest that stimulation of an α-adrenergic postsynaptic receptor is of importance for the stimulant effect of CRL 40028. © 1979.

引用

页码：121 / 123

页数：3

共 10 条

[1] ADRENERGIC-RECEPTOR BLOCKING-AGENTS - EFFECTS ON CENTRAL NORADRENALINE AND DOPAMINE RECEPTORS AND ON MOTOR ACTIVITY [J].