APPLICATION OF ACCELERATOR MASS-SPECTROMETRY IN ALUMINUM METABOLISM STUDIES

被引：28

作者：

MEIRAV, O

SUTTON, RAL

FINK, D

MIDDLETON, R

KLEIN, J

WALKER, VR

HALABE, A

VETTERLI, D

JOHNSON, RR

机构：

[1] UNIV BRITISH COLUMBIA, DEPT PHYS, VANCOUVER V6T 1W5, BC, CANADA

[2] UNIV BRITISH COLUMBIA, DEPT MED, VANCOUVER V6T 1W5, BC, CANADA

[3] UNIV PENN, DEPT PHYS, PHILADELPHIA, PA 19104 USA

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 1990年 / 52卷 / 3-4期

关键词：

D O I：

10.1016/0168-583X(90)90472-7

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The recent recognition that aluminum causes toxicity in uremic patients and may be associated with Alzheimer's disease has stimulated many studies of its biochemical effects. However, such studies were hampered by the lack of a suitable tracer. In a novel experiment, we have applied the new technique of accelerator mass spectrometry to investigate aluminum kinetics in rats, using as a marker the long-lived isotope Al-26. We present the first aluminum kinetic model for a biological system. The results clearly demonstrate the advantage this technique holds for isotope tracer studies in animals as well as in humans.

引用

页码：536 / 539

页数：4

共 24 条

[1] DIALYSIS ENCEPHALOPATHY SYNDROME - POSSIBLE ALUMINUM INTOXICATION [J].