PROGRESS AND APPROACHES IN MAPPING THE SURFACES OF HUMAN FOLLICLE-STIMULATING-HORMONE - COMPARISON WITH THE OTHER HUMAN PITUITARY GLYCOPROTEIN HORMONES

被引:34
作者
DIAS, JA [1 ]
机构
[1] SUNY ALBANY,SCH PUBL HLTH,DEPT BIOMED SCI,ALBANY,NY 12201
关键词
D O I
10.1016/1043-2760(92)90088-I
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The pituitary glycoprotein hormones, including human follicle-stimulating hormone (hFSH), are involved in the physiologic functions of receptor binding, in subunit association during assembly and processing, and in untoward effects such as antibody formation during clinical intervention. These activities derive from specific macromolecular associations; a major research trend has been to map the surfaces of these glycoprotein hormones (hFSH, hLH, hCG, and hTSH) into discrete areas responsible for each activity by using a variety of biochemical approaches. Each surface domain or determinant of the hormone is likely to comprise discontinuous amino acid sequences, from one or both subunits, assembled into a precise, unique, macromolecular surface. The paradigm of antigen-antibody interaction may help to explain how the surfaces are assembled, how the common alpha-subunit combines with the unique beta-subunit of each, and how the receptor interacts with heterodimeric hormone.
引用
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页码:24 / 29
页数:6
相关论文
共 32 条
[1]   EPITOPE MAPPING OF HUMAN LUTEINIZING-HORMONE USING MONOCLONAL-ANTIBODIES [J].
ALONSOWHIPPLE, C ;
COUET, ML ;
DOSS, R ;
KOZIARZ, J ;
OGUNRO, EA ;
CROWLEY, WF .
ENDOCRINOLOGY, 1988, 123 (04) :1854-1860
[2]   MONOCLONAL-ANTIBODIES DIRECTED TO HUMAN AND EQUINE CHORIONIC GONADOTROPINS AS PROBES FOR THE TOPOGRAPHIC ANALYSIS OF EPITOPES ON THE HUMAN ALPHA-SUBUNIT [J].
BIDART, JM ;
TROALEN, F ;
BOUSFIELD, GR ;
BOHUON, C ;
BELLET, D .
ENDOCRINOLOGY, 1989, 124 (02) :923-929
[3]   PEPTIDE IMMUNOGEN MIMICRY OF A PROTEIN-SPECIFIC STRUCTURAL EPITOPE ON HUMAN CHORIOGONADOTROPIN [J].
BIDART, JM ;
TROALEN, F ;
GHILLANI, P ;
ROUAS, N ;
RAZAFINDRATSITA, A ;
BOHUON, C ;
BELLET, D .
SCIENCE, 1990, 248 (4956) :736-739
[4]  
BIRKEN S, 1987, ENDOCRINOLOGY, V112, P657
[5]  
BOUSFIELD GR, 1988, J BIOL CHEM, V263, P12602
[6]   CONVERSION OF HUMAN CHORIOGONADOTROPIN INTO A FOLLITROPIN BY PROTEIN ENGINEERING [J].
CAMPBELL, RK ;
DEANEMIG, DM ;
MOYLE, WR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (03) :760-764
[7]  
CHATURVEDI S, 1990, INT J PEPT PROT RES, V35, P133
[8]   THE RELATION BETWEEN THE DIVERGENCE OF SEQUENCE AND STRUCTURE IN PROTEINS [J].
CHOTHIA, C ;
LESK, AM .
EMBO JOURNAL, 1986, 5 (04) :823-826
[9]  
COLOMA TAS, 1990, J BIOL CHEM, V265, P5037
[10]   A SYNTHETIC PEPTIDE CORRESPONDING TO HUMAN-FSH-BETA-SUBUNIT 33-53 BINDS TO FSH RECEPTOR, STIMULATES BASAL ESTRADIOL BIOSYNTHESIS, AND IS A PARTIAL ANTAGONIST OF FSH [J].
COLOMA, TAS ;
DATTATREYAMURTY, B ;
REICHERT, LE .
BIOCHEMISTRY, 1990, 29 (05) :1194-1200