A MOUSE TGF-BETA TYPE-I RECEPTOR THAT REQUIRES TYPE-II RECEPTOR FOR LIGAND-BINDING

被引：38

作者：

SUZUKI, A ^{[1
]}

SHIODA, N ^{[1
]}

MAEDA, T ^{[1
]}

TADA, M ^{[1
]}

UENO, N ^{[1
]}

机构：

[1] HOKKAIDO UNIV, FAC PHARMACEUT SCI, SAPPORO, HOKKAIDO 060, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 198卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1151

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA for a serine/threonine kinase receptor was isolated from a mouse brain cDNA library. The receptor transiently expressed on COS cells bound TGF-β1 not by itself but only when TGF-β type II receptor was coexpressed. The molecular mass of the ligand-receptor complex was estimated to be 75 kDa. The type 11 receptor-dependent binding and the molecular mass of the complex suggest that the receptor is a TGF-β type I receptor. © 1994 Academic Press. All rights reserved.

引用

页码：1063 / 1069

页数：7

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