RETT-SYNDROME - 3-D CONFOCAL MICROSCOPY OF CORTICAL PYRAMIDAL DENDRITES AND AFFERENTS

被引：183

作者：

BELICHENKO, PV

OLDFORS, A

HAGBERG, B

DAHLSTROM, A

机构：

[1] GOTHENBURG UNIV, FAC MED, INST NEUROBIOL, DEPT ANAT & CELL BIOL, S-41390 GOTHENBURG, SWEDEN

[2] RUSSIAN ACAD MED SCI, INST BRAIN RES, MOSCOW, RUSSIA

[3] GOTHENBURG UNIV, FAC MED, DEPT NEUROPATHOL, S-41390 GOTHENBURG, SWEDEN

[4] GOTHENBURG UNIV, FAC MED, DEPT PAEDIAT NEUROL, S-41390 GOTHENBURG, SWEDEN

来源：

NEUROREPORT | 1994年 / 5卷 / 12期

关键词：

RETT SYNDROME; HUMAN CORTEX; INTRACELLULAR STAINING; LUCIFER YELLOW; DENDRITIC MORPHOLOGY; CARBOCYANINE DYES; AFFERENTS; 3-D RECONSTRUCTION; CONFOCAL MICROSCOPY;

D O I：

10.1097/00001756-199407000-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AUTOPSY material from three patients with Rett syndrome and six control cases (frontal, temporal and motor cortical areas) were studied. Pyramidal and non-pyramidal neurones, 100-200 in each specimen, were visualized by Lucifer Yellow microinjection. 3-D reconstructions and rotations were computed using the VoxelView/GT program. Various types of abnormalities in 3-D dendritic architecture of pyramidal neurones in different cortices were observed. Some pyramidal cells in layers II-III had a subnormal number of dendrites. The normally occurring specializations in pyramidal architecture in different cortical areas were absent. Decreased numbers and regional loss ('naked' areas) of dendritic spines were found. Widely distributed cortical afferents were shown by the carbocyanine dye (DiI) tracing method. PAD showed no microdysgenesis, in contrast to the observations in epilepsy.

引用

页码：1509 / 1513

页数：5

共 21 条

[1]

ARMSTRONG DD, 1992, BRAIN DEV-JPN, V14, pS89

[2]

BELICHENKO PV, 1991, ARCH ANAT HISTOL EMB, V101, P81

[3]

BELICHENKO PV, IN PRESS HUMAN BRAIN

[4]

BELICHENKO PV, 1992, BIOTECHNOLOGY APPLIC, P29