THE SINGLE PSEUDOURIDINE RESIDUE IN ESCHERICHIA-COLI 16S RNA IS LOCATED AT POSITION-516

被引：56

作者：

BAKIN, A

KOWALAK, JA

MCCLOSKEY, JA

OFENGAND, J

机构：

[1] ROCHE INST MOLEC BIOL,ROCHE RES CTR,NUTLEY,NJ 07110

[2] UNIV UTAH,DEPT BIOCHEM,SALT LAKE CITY,UT 84112

[3] UNIV UTAH,DEPT MED CHEM,SALT LAKE CITY,UT 84112

来源：

NUCLEIC ACIDS RESEARCH | 1994年 / 22卷 / 18期

关键词：

D O I：

10.1093/nar/22.18.3681

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number and location of pseudouridine residues in Escherichia coli 16S ribosomal RNA has been determined by a combination of direct and indirect methods. Only one residue was found, at position 516. This site is at the 5'-end of one of the three most highly conserved long sequences of this RNA molecule. A number of experimental findings have strongly implicated this loop in the fidelity of codon recognition by A-site bound tRNA. By virtue of its location, we suggest that Psi 516 may also play a role in maintaining the fidelity of protein synthesis.

引用

页码：3681 / 3684

页数：4

共 43 条

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