SYNTHETIC CARBOHYDRATE VACCINES BASED ON TUMOR-ASSOCIATED ANTIGENS

The confluence of chemistry and immunology has cultivated a growing number of collaboratory studies leading to major advances in both fields. The development of synthetic vaccines is just one of them. This review describes a brief overview of the recent progress in synthetic cancer vaccines based on tumour-associated carbohydrate antigens, especially the blood group related antigens of epithelial cancers including Tn (GalNAc alpha 1-->0-Ser/Thr), sialosyl Tn (NeuAc alpha 2-->6GalNAc alpha 1-->0-Ser/Thr), and T (Gal beta 1-->3GalNAc alpha 1-->0-Ser/Thr) antigens.