MONTE-CARLO SIMULATED ANNEALING PREDICTION FOR ALPHA-HELIX PROPENSITY OF AMINO-ACID HOMOPOLYMERS

被引：16

作者：

FUKUGITA, M

NAKAZAWA, T

KAWAI, H

OKAMOTO, Y

机构：

[1] NARA WOMENS UNIV, DEPT CHEM, NARA 630, JAPAN

[2] NARA WOMENS UNIV, DEPT PHYS, NARA 630, JAPAN

[3] UNIV TOKYO, DEPT PHYS, TOKYO 113, JAPAN

来源：

CHEMISTRY LETTERS | 1991年 / 07期

关键词：

D O I：

10.1246/cl.1991.1279

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monte Carlo simulated annealing calculation is carried out for various homopolymers of amino acid with 5-15 residues. Conspicuous alpha-helix propensity is found for poly-L-Met and poly-L-Lys. We also found that alpha-helices are hardly formed in poly-Gly and poly-L-Tyr. This alpha-helix propensity observed in the simulation is in excellent agreement with the empirical rule derived from synthetic homopolymers and from statistical analyses of peptide data bases.

引用

页码：1279 / 1282

页数：4

共 19 条

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