ENHANCED PRODUCTION OF PLATELET-ACTIVATING-FACTOR IN STIMULATED RAT LEUKOCYTES PRETREATED WITH TRIACSIN-C, A NOVEL ACYL-COA SYNTHETASE INHIBITOR

被引：22

作者：

HAYASHI, M ^{[1
]}

IMAI, Y ^{[1
]}

NARABA, H ^{[1
]}

TOMODA, H ^{[1
]}

OMURA, S ^{[1
]}

OHISHI, S ^{[1
]}

机构：

[1] KITASATO INST,MINATO KU,TOKYO 108,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 188卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91370-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triacsin C, a product of Streptmyces sp. SK-1894, was previously reported as an inhibitor of long chain acyl-CoA synthetase. Pretreatment with triacsin C (500 nM) for 1h enhanced production of platelet-activating factor in rat neutrophils, followed by stimulation with A23187 or fMLP. Amount of lyso-PAF was also augumented. Triacsin C alone did not increase PAF content and did not modulate enzymatic activities of acytransferase, cholinephosphotransferase, acetylhydrolase, acetyltransferase or phospholipase A2. These results suggest that triacsin C might enhance supply of substrate for PAF synthesis, i.e. accumulation of lyso-PAF by interfering reacylation pathway. © 1992.

引用

页码：1280 / 1285

页数：6

共 22 条

[1] RELEASE OF ARACHIDONIC-ACID FROM 1-ALKYL-2-ACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, A PRECURSOR OF PLATELET-ACTIVATING FACTOR, IN RAT ALVEOLAR MACROPHAGES [J].