NEW ANTIMICROBIAL FILICINIC ACID-DERIVATIVES FROM HYPERICUM-DRUMMONDII

被引：61

作者：

JAYASURIYA, H

CLARK, AM

MCCHESNEY, JD

机构：

[1] UNIV MISSISSIPPI,DEPT PHARMACOGNOSY,UNIVERSITY,MS 38677

[2] UNIV MISSISSIPPI,PHARMACEUT SCI RES INST,UNIVERSITY,MS 38677

来源：

JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 05期

关键词：

D O I：

10.1021/np50077a013

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioactivity-guided fractionation of the hexane extract of the stems and leaves of Hypericum drummondii has afforded four new filicinic acid derivatives: drummondin D [1], isodrummondin D [2], drummondin E [3], and drummondin F [4]. The structures of these compounds were established by spectroscopic methods. All compounds possessed strong antibiotic activity against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the acid fast bacterium Mycobacterium smegmatis.

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页码：1314 / 1320

页数：7

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