POLYADENYLIC - POLYURIDYLIC ACID-INDUCED PROTECTION OF BALB/C MICE AGAINST ACUTE MURINE CYTOMEGALOVIRUS-INFECTION

被引：3

作者：

ADAMS, A ^{[1
]}

MOHRMAN, M ^{[1
]}

JOHNSON, AG ^{[1
]}

MORIN, A ^{[1
]}

DEPAILLETTE, ED ^{[1
]}

机构：

[1] INST HENRI BEAUFOUR, PARIS, FRANCE

来源：

JOURNAL OF GENERAL VIROLOGY | 1992年 / 73卷

关键词：

D O I：

10.1099/0022-1317-73-9-2409

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Treatment of BALB/c mice with poly(A): poly(U) 18 h prior to infection with a lethal dose of murine cytomegalovirus (MCMV) increased survival. In parallel with increased survival, a 10- to 100-fold reduction of plaque-forming MCMV was found in the liver and spleen of mice 4 days post-infection with a sublethal dose of MCMV. Poly(A): poly(U) did not significantly increase natural killer cell activity or prolong the duration of elevated cytotoxic activity in infected animals. The possible role of interferon in the poly(A): poly(U)-induced protection of BALB/c mice is discussed.

引用

页码：2409 / 2413

页数：5

共 29 条

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