TRIIODOTHYRONINE (T3) STIMULATES INSULIN-LIKE GROWTH-FACTOR (IGF)-1 AND IGF BINDING-PROTEIN (IGFBP)-2 PRODUCTION BY RAT OSTEOBLASTS INVITRO

被引：55

作者：

SCHMID, C ^{[1
]}

SCHLAPFER, I ^{[1
]}

FUTO, E ^{[1
]}

WALDVOGEL, M ^{[1
]}

SCHWANDER, J ^{[1
]}

ZAPF, J ^{[1
]}

FROESCH, ER ^{[1
]}

机构：

[1] KANTONSSPITAL,ZENTRUM LEHRE & FORSCHUNG,CH-4004 BASEL,SWITZERLAND

来源：

ACTA ENDOCRINOLOGICA | 1992年 / 126卷 / 05期

关键词：

D O I：

10.1530/acta.0.1260467

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Osteoblast-like cells prepared from neonatal rat calvariae and grown under serum-free conditions produce IGF-1 and IGFBPs. In contrast to growth hormone, T3 and PTH increased both IGF-1 mRNA expression and net IGF-1 release in calvaria cells. In addition, they stimulated net production of IGFBP-3 and of an IGFBP with an apparent molecular weight of 32 kDa which was recognized by an antiserum against rat IGFBP-2. Bone cells expressed remarkably high levels of mRNA for IGFBP-2, the predominant IGFBP in serum of newborn rats. T3 at low physiological concentrations but not growth hormone stimulated IGFBP-2 mRNA expression and IGFBP-2 production in bone cells in vitro. Thus, IGFBPs are differentially regulated by these hormones and may play an autocrine/paracrine regulatory role in bone.

引用

页码：467 / 473

页数：7

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