ALTERATIONS OF THE GLUTATHIONE CYCLE ENZYMES DURING AND AFTER SV40-TRANSFORMATION OF HUMAN FIBROBLASTS

被引:15
作者
BRAVARD, A
HOFFSCHIR, F
RICOUL, M
CASSINGENA, R
ESTRADE, S
LUCCIONI, C
DUTRILLAUX, B
机构
[1] CEA, DVS, DPTE, LCG, BP6, F-92265 FONTENAY AUX ROSES, FRANCE
[2] IRSC, UPR 42, F-94802 VILLEJUIF, FRANCE
[3] INST CURIE, BIOL SECT, CNRS, URA 620, F-75231 PARIS 05, FRANCE
关键词
D O I
10.1093/carcin/14.1.21
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The activities of several enzymes involved in the antioxidant system of the cell were studied in parallel to cytogenetic alterations at various times after SV40 infection and transformation of human fibroblasts. At early passages after SV40 injection, glutathione reductase (GSR), glutathione peroxidase (GPX), glutathione transferase (GST) and glucose-6-phosphate dehydrogenase (G6PD) activities were decreased. This, associated with the low superoxide dismutase (SOD) and catalase activities previously noticed in these cells, suggested that they are in a highly pro-oxidant status. Although chromosomes carrying the genes encoding these enzymes are frequently underrepresented, there is no direct relationship between the number of chromosomes and enzyme activities. Except for GPX, all the activities tend to increase in established cell lines reaching levels comparable to those of non-transformed fibroblasts. The late increase of G6PD activity may correlate with the frequent duplication of the early replicating X. GSR seems to correlate with G6PD activity and GPX to SOD total activity. The most striking alterations affect mitochondrial and peroxisomal enzymes activities: SOD, GPX and catalase.
引用
收藏
页码:21 / 24
页数:4
相关论文
共 34 条
[1]   INACTIVATION OF GLUTATHIONE-PEROXIDASE BY SUPEROXIDE RADICAL [J].
BLUM, J ;
FRIDOVICH, I .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 240 (02) :500-508
[2]  
BOREK C, 1987, British Journal of Cancer, V55, P74
[3]   SOD2 - A NEW TYPE OF TUMOR-SUPPRESSOR GENE [J].
BRAVARD, A ;
SABATIER, L ;
HOFFSCHIR, F ;
RICOUL, M ;
LUCCIONI, C ;
DUTRILLAUX, B .
INTERNATIONAL JOURNAL OF CANCER, 1992, 51 (03) :476-480
[4]   EARLY SUPEROXIDE-DISMUTASE ALTERATIONS DURING SV40-TRANSFORMATION OF HUMAN FIBROBLASTS [J].
BRAVARD, A ;
HOFFSCHIR, F ;
SABATIER, L ;
RICOUL, M ;
PINTON, A ;
CASSINGENA, R ;
ESTRADE, S ;
LUCCIONI, C ;
DUTRILLAUX, B .
INTERNATIONAL JOURNAL OF CANCER, 1992, 52 (05) :797-801
[5]   SELENIUM-DEPENDENT AND NON-SELENIUM-DEPENDENT GLUTATHIONE PEROXIDASES IN HUMAN-TISSUE EXTRACTS [J].
CARMAGNOL, F ;
SINET, PM ;
JEROME, H .
BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 759 (1-2) :49-57
[6]  
CERRUTTI PA, 1985, SCIENCE, V227, P375
[7]  
CERUTTI PA, 1991, CANCER CELL-MON REV, V3, P1
[8]   ASSIGNMENT OF T-ANTIGEN GENE OF SIMIAN VIRUS 40 TO HUMAN CHROMOSOME C-7 [J].
CROCE, CM ;
GIRARDI, AJ ;
KOPROWSKI, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (12) :3617-3620
[9]   SUPEROXIDE RADICALS AND HYDROGEN-PEROXIDE FORMATION IN MITOCHONDRIA FROM NORMAL AND NEOPLASTIC TISSUES [J].
DIONISI, O ;
GALEOTTI, T ;
TERRANOVA, T ;
AZZI, A .
BIOCHIMICA ET BIOPHYSICA ACTA, 1975, 403 (02) :292-300
[10]  
Dutrillaux B, 1981, PRATIQUE ANAL CHROMO