TC-99M LABELED BIOTIN CONJUGATE IN A TUMOR PRETARGETING APPROACH WITH MONOCLONAL-ANTIBODIES

被引：20

作者：

KOCH, P ^{[1
]}

MACKE, HR ^{[1
]}

机构：

[1] UNIV SPITAL BASEL,INST NUKL MED,PETERSGRABEN 4,CH-4031 BASEL,SWITZERLAND

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 11期

关键词：

D O I：

10.1002/anie.199215071

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Very stable in vitro and in vivo, the complex of Tc-99m and the biotin derivative 1 shows, like biotin, a high affinity for the glycoprotein avidin. It was successfully used to diagnose brain tumors when the patients were treated three days previously with an unlabeled conjugate of a tumor-specific monoclonal antibody and avidin.

引用

页码：1507 / 1509

页数：3

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