KINASE BYPASS - A NEW STRATEGY FOR ANTI-HIV DRUG DESIGN

被引：24

作者：

MCGUIGAN, C

KINCHINGTON, D

NICHOLLS, SR

NICKSON, C

OCONNOR, TJ

机构：

[1] UNIV LONDON UNIV COLL,DEPT CHEM,LONDON WC1H 0AJ,ENGLAND

[2] ST BARTHOLOMEWS HOSP MED COLL,DEPT VIROL,LONDON EC1A 7BE,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80316-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The 5'-bis(trichloroethyl) phosphate derivatives of several 3'-O-acyl thymidines were prepared from the thymidine phosphate. Even though the parent nucleosides are inactive as antiviral agents, the phosphates are selective inhibitors of the proliferation of HIV. This activity is attributed to a new mechanism of action, we herein describe as ''kinase by-pass''.

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页码：1207 / 1210

页数：4

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