A POTENT ANTI-TUMOR QUINAZOLINE INHIBITOR OF THYMIDYLATE SYNTHETASE - SYNTHESIS, BIOLOGICAL PROPERTIES AND THERAPEUTIC RESULTS IN MICE

被引：307

作者：

JONES, TR ^{[1
]}

CALVERT, AH ^{[1
]}

JACKMAN, AL ^{[1
]}

BROWN, SJ ^{[1
]}

JONES, M ^{[1
]}

HARRAP, KR ^{[1
]}

机构：

[1] INST CANC RES, DEPT BIOCHEM PHARMACOL, SUTTON SM2 5PX, SURREY, ENGLAND

来源：

EUROPEAN JOURNAL OF CANCER | 1981年 / 17卷 / 01期

关键词：

D O I：

10.1016/0014-2964(81)90206-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：11 / 19

页数：9

共 45 条

[1] NEW SYNTHETIC ROUTE TO QUINAZOLINE ANALOGS OF FOLIC-ACID [J].

ACHARYA, SP ;

HYNES, JB .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1975, 12 (06) :1283-1286

[2] LESSONS FROM CHORIOCARCINOMA [J].

BAGSHAWE, KD .

PROCEEDINGS OF THE ROYAL SOCIETY OF MEDICINE-LONDON, 1977, 70 (05) :303-306

[3] AMINO-ACID SEQUENCE AT FDUMP BINDING-SITE OF THYMIDYLATE SYNTHETASE [J].

BELLISARIO, RL ;

MALEY, GF ;

GALIVAN, JH ;

MALEY, F .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (06) :1848-1852

[4]

BIRD OD, 1970, MOL PHARMACOL, V6, P573

[5]

BORSA J, 1969, CANCER RES, V29, P737

[6]

CALVERT AH, 1979, P AM ASSOC CANC RES, V20, P24

[7] QUINAZOLINE ANTIFOLATES WITH DUAL BIOCHEMICAL LOCI OF ACTION - BIOCHEMICAL AND BIOLOGICAL STUDIES DIRECTED TOWARDS OVERCOMING METHOTREXATE RESISTANCE [J].

CALVERT, AH ;

JONES, TR ;

DADY, PJ ;

GRZELAKOWSKASZTABERT, B ;

PAINE, RM ;

TAYLOR, GA ;

HARRAP, KR .

EUROPEAN JOURNAL OF CANCER, 1980, 16 (05) :713-722

[8]

CALVERT AH, 1980, ADV TUMOUR PREVENT, V5, P272

[9]

CARLIN SC, 1974, MOL PHARMACOL, V10, P194

[10] STRUCTURES OF REVERSIBLE AND IRREVERSIBLE COMPLEXES OF THYMIDYLATE SYNTHETASE AND FLUORINATED PYRIMIDINE NUCLEOTIDES [J].

DANENBER.PV ;

LANGENBA.RJ ;

HEIDELBE.C .

BIOCHEMISTRY, 1974, 13 (05) :926-933

← 1 2 3 4 5 →