A SEQUENTIAL APPROACH TO TESTING WITH THE RODENT BONE-MARROW MICRONUCLEUS ASSAY - OBVIATION OF THE NEED FOR STATISTICAL-ANALYSES OF DATA

被引：9

作者：

ASHBY, J

TINWELL, H

机构：

[1] Zeneca Central Toxicology Laboratory, Macclesfield, Cheshire SK10 4TJ, Alderley Park

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1995年 / 327卷 / 1-2期

关键词：

MICRONUCLEUS ASSAY PROTOCOL;

D O I：

10.1016/0027-5107(95)93252-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The 'sequential' protocol we use for the conduct of mouse bone marrow micronucleus assays is described. The most important criterion for activity in the assay is the reproducibility of any induced effects. The frequencies of micronucleated polychromatic erythrocytes among 239 male CBA control mice are displayed and discussed. Our decision to avoid statistical analysis when assessing mouse bone marrow micronucleus data is explained.

引用

页码：49 / 55

页数：7

共 15 条

[1]

[Anonymous], 1989, STAT EVALUATION MUTA

[2]

ASHBY J, 1991, MUTAT RES, V257, P309

[3]

Bauval R., 1994, ORION MYSTERY

[4] STATISTICAL-ANALYSIS OF DATA IN MUTAGENICITY ASSAYS - RODENT MICRONUCLEUS ASSAY [J].