A GRADIENT HPLC METHOD FOR QUANTITATION OF CYCLOSPORINE AND ITS METABOLITES IN BLOOD AND BILE

被引:27
作者
BOWERS, LD
SINGH, J
机构
[1] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, United States
来源
JOURNAL OF LIQUID CHROMATOGRAPHY | 1987年 / 10卷 / 2-3期
关键词
We would like to thank Dr. R. Voges of Sandoz for the gift of tritium labelled cyclosporine and Dr. G. Mauer for the donation of a small amount of four of the CsA metabolites. We would also like to acknowledge the assistance of Dr. K. Sukalski and Dr. R. Nordlie of the University of North Dakota who did the liver perfusion work; the details of which will be reported elsewhere. This work was supported in part by the Core Research Center for Study of Advanced Liver Disease at the University of Minnesota (MH 1 P30 AM34931-01) and the American Diabetes Association Minnesota Affiliate;
D O I
10.1080/01483918708066725
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
6
引用
收藏
页码:411 / 420
页数:10
相关论文
共 6 条
[1]   INVESTIGATION OF THE MECHANISM OF PEAK BROADENING OBSERVED IN THE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ANALYSIS OF CYCLOSPORINE [J].
BOWERS, LD ;
MATHEWS, SE .
JOURNAL OF CHROMATOGRAPHY, 1985, 333 (01) :231-238
[2]  
BOWERS LD, 1985, TDM, V7, P1
[3]   EVALUATION OF CYCLOSPORIN PHENYTOIN INTERACTION WITH OBSERVATIONS ON CYCLOSPORIN METABOLITES [J].
FREEMAN, DJ ;
LAUPACIS, A ;
KEOWN, PA ;
STILLER, CR ;
CARRUTHERS, SG .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1984, 18 (06) :887-893
[4]   ROLE OF LIPOPROTEINS AND ERYTHROCYTES IN THE INVITRO BINDING AND DISTRIBUTION OF CYCLOSPORIN-A IN THE BLOOD [J].
LEMAIRE, M ;
TILLEMENT, JP .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 1982, 34 (11) :715-718
[5]  
LENSMEYER GL, 1985, CLIN CHEM, V31, P196
[6]  
ROSANO TG, 1986, IN PRESS TRANSPLANTA