ANTIMETASTATIC AND GROWTH-INHIBITORY EFFECTS OF N-ACETYLCHITOHEXAOSE IN MICE BEARING LEWIS LUNG-CARCINOMA

被引：82

作者：

TSUKADA, K

MATSUMOTO, T

AIZAWA, K

TOKORO, A

NARUSE, RS

SUZUKI, S

SUZUKI, M

机构：

[1] TOHOKU COLL PHARMACEUT SCI,DEPT MICROBIOL,KOMATSUSHIMA 4-4-1,AOBA KU,SENDAI,MIYAGI 981,JAPAN

[2] TOHOKU COLL PHARMACEUT SCI,DEPT HYG CHEM 2,AOBA KU,SENDAI,MIYAGI 981,JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 03期

关键词：

Lewis lung carcinoma; Lung metastasis; N‐Acetylchitohexaose;

D O I：

10.1111/j.1349-7006.1990.tb02559.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

N‐Acetylchitohexaose, a water‐soluble oligosaccharide was found to display a significant anti‐metastatic effect against Lewis lung carcinoma (LLC) transplanted into C57BL/6 mice, giving rise to a 40–50% inhibition ratio of pulmonary metastasis when administered intravenously (1 mg/kg) on day 6 after the tumor implantation (5 × 105 cells/mouse). It was also revealed that this hexaose had a significant growth‐inhibitory effect against the local tumor of the same carcinoma (a 20–30% inhibition ratio), showing an enhancing effect on concomitant immunity in local tumor‐resected mice. This oligosaccharide was also shown to enhance the tumoricidal effect of splenic T lymphocytes against LLC and P‐815 mastocytoma cells and to increase the natural killer activity of splenic T lymphocytes, assayed with YAC‐1 cells as the target. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：259 / 265

页数：7

共 19 条

[1]

FIDLER IJ, 1982, CANCER RES, V42, P496

[2]

HANNA N, 1981, J IMMUNOL, V127, P1754

[3]

HASHIMOTO K, 1983, J PHARMACOBIO-DYNAM, V6, P668

[4] ANTITUMOR EFFECT OF THE YEAST POLYSACCHARIDE PREPARATION IN SYNGENEIC MOUSE-TUMOR MODELS [J].