SEROTONIN UPTAKE IN SCHISTOSOMULES OF SCHISTOSOMA-MANSONI

被引：43

作者：

CATTO, BA

OTTESEN, EA

机构：

[1] Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-PHARMACOLOGY TOXICOLOGY & ENDOCRINOLOGY | 1979年 / 63卷 / 02期

关键词：

D O I：

10.1016/0306-4492(79)90067-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Schistosomules contain 1 5 the concentration of serotonin of adult male schistosomes. 2. Serotonin uptake in schistosomules is a temperature dependent, saturable transport process below 6 μM. 3. Saturable uptake is inhibited by ouabain, fluoxetine, and tryptamine. 4. Saturable uptake has a Km of 1.7 μM and a Vmax of 0.3 pmol/min/1000 schistosomules. 5. During the first hour after uptake serotonin is not metabolized to 5-HIAA. © 1979.

引用

页码：235 / 242

页数：8

共 27 条

[1] SEPARATION AND DETECTION OF BIOGENIC AMINES BY THIN-LAYER CHROMATOGRAPHY - MICRO-ANALYSIS OF TISSUE AMINES AND OF ENZYMES INVOLVED IN THEIR METABOLISM [J].

AURES, D ;

FLEMING, R ;

HAKANSON, R .

JOURNAL OF CHROMATOGRAPHY, 1968, 33 (3-4) :480-+

[2]

BENNETT J, 1969, MOL PHARMACOL, V5, P542

[3]

BENNETT JL, 1973, MOL PHARMACOL, V9, P311

[4]

Bueding E, 1972, P95

[5] 5-HYDROXYTRYPTAMINE AND DOPAMINE IN BIOMPHALARIA-GLABRATA [J].

CHIANG, PK ;

BOURGEOIS, JG ;

BUEDING, E .

JOURNAL OF PARASITOLOGY, 1974, 60 (02) :264-271

[6] OCCURRENCE AND CONCENTRATIONS OF BIOGENIC-AMINES IN TREMATODES [J].

CHOU, TCT ;

BENNETT, J ;

BUEDING, E .

JOURNAL OF PARASITOLOGY, 1972, 58 (06) :1098-1102

[7]

Clegg J A, 1972, Int J Parasitol, V2, P79, DOI 10.1016/0020-7519(72)90036-7

[8] PLASMA FREE SEROTONIN (5 HYDROXYTRYPTAMINE) [J].

CRAWFORD, N .

CLINICA CHIMICA ACTA, 1963, 8 (01) :39-&

[9] SCHISTOSOMA-MANSONI - BIOCHEMICAL EVIDENCE FOR MORPHOGENETIC CHANGE FROM CERCARIA TO SCHISTOSOMULE [J].

GAZZINELLI, G ;

OLIVEIRA, CC ;

FIGUEIREDO, EA ;

PEREIRA, LH ;

COELHO, PMZ ;

PELLEGRINO, J .

EXPERIMENTAL PARASITOLOGY, 1973, 34 (02) :181-188

[10]

GUILBAULT GG, 1974, CLIN CHEM, V20, P812

← 1 2 3 →