A NEW, HIGHLY EFFICIENT METHOD FOR ISOCARBACYCLIN SYNTHESIS BASED ON TANDEM CLAISEN REARRANGEMENT AND ENE REACTIONS

被引：40

作者：

MANDAI, T ^{[1
]}

MATSUMOTO, S ^{[1
]}

KOHAMA, M ^{[1
]}

KAWADA, M ^{[1
]}

TSUJI, J ^{[1
]}

SAITO, S ^{[1
]}

MORIWAKE, T ^{[1
]}

机构：

[1] OKAYAMA UNIV,FAC ENGN,DEPT APPL CHEM,OKAYAMA 700,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 22期

关键词：

D O I：

10.1021/jo00309a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

: A new short-step synthesis of isocarbacyclin is described which features a crucial single-pot, three-step transformation, i.e., tandem tertiary allylic vinyl ether formation, Claisen rearrangement, and ene cyclization, to lead to a bicyclo[3.3.0] framework, overcoming previous endocyclic double bond and one-carbon elongation problems. © 1990, American Chemical Society. All rights reserved.

引用

页码：5671 / 5673

页数：3

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