INVESTIGATION OF SPECIES-DIFFERENCES IN ISOBUTENE (2-METHYLPROPENE) METABOLISM BETWEEN MICE AND RATS

被引:15
作者
CSANADY, GA
FREISE, D
DENK, B
FILSER, JG
CORNET, M
ROGIERS, V
LAIB, RJ
机构
[1] UNIV DORTMUND,INST ARBEITSPHYSIOL,W-4600 DORTMUND,GERMANY
[2] GESELL STRAHLEN & UMWELTFORSCH MBH,INST TOXIKOL,W-8042 NEUHERBERG,GERMANY
[3] FREE UNIV BRUSSELS,DEPT TOXICOL,B-1050 BRUSSELS,BELGIUM
关键词
ISOBUTENE (2-METHYLPROPENE); 1,1-DIMETHYLOXIRANE; PHARMACOKINETICS; INHALATION; EPOXIDE FORMATION; SPECIES DIFFERENCES;
D O I
10.1007/BF02034934
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
Metabolism of isobutene (2-methylpropene) in rats (Sprague Dawley) and mice (B6C3F1) follows kinetics according to Michaelis-Menten. The maximal metabolic elimination rates are 340-mu-mol/kg/h for rats and 560-mu-mol/kg/h for mice. The atomospheric concentration at which V(max)/2 is reached is 1200 ppm for rats and 1800 ppm for mice. At steady state, below atmospheric concentrations of about 500 ppm the rate of metabolism of isobutene is direct proportional to its concentration. 1,1-Dimethyloxirane is formed as a primary reactive intermediate during metabolism of isobutene in rats and can be detected in the exhaled air of the animals. Under conditions of saturation of isobutene metabolism the concentration of 1,1-dimethyloxirane in the atmosphere of a closed exposure system is only about 1/15 of that observed for ethene oxide and about 1/100 of that observed for 1,2-epoxy-3-butene as intermediates in the metabolism of ethene or 1,3-butadiene.
引用
收藏
页码:100 / 105
页数:6
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