ENDOGENOUS OPIOIDS ARE INVOLVED IN THE GENETICALLY-DETERMINED HIGH PREFERENCE FOR ETHANOL-CONSUMPTION

被引：66

作者：

GEORGE, SR ^{[1
]}

ROLDAN, L ^{[1
]}

LUI, A ^{[1
]}

NARANJO, CA ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT MED,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1991年 / 15卷 / 04期

关键词：

ALCOHOL; ENDOGENOUS OPIOID PEPTIDES; ENKEPHALINASE; MET-ENKEPHALIN; PROENKEPHALIN;

D O I：

10.1111/j.1530-0277.1991.tb00576.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The link between endogenous opioid peptides and the genetic predisposition to preferentially consume ethanol was examined in alcohol preferring C57BL/6J mice compared with the alcohol nonpreferring DBA/2 mice. Concentrations of Met-enkephalin pentapeptide or precursor in various brain regions of potential relevance were not different between the two strains. C57BL/6J mice had a significantly lower pain threshold that could be increased by a selective mureceptor opioid agonist [D-Ala2, MePhe4, Met(O)5-ol]-enkephalin. Treatment with this drug also decreased ethanol consumption in C57BL/6J mice. Increasing the synaptic half-life of endogenous enkephalins by the enkephalinase inhibitor kelatorphan also decreased ethanol consumption. Assay of endogenous enkephalin degrading activity showed increased enkephalinase activity in striatal issue of C57BL/6J compared with DBA/2 tissue. These results suggest that a relative lack of enkephalin peptides trans-synaptically, possibly resulting from enhanced enkephalin degradation may contribute to increase alcohol consumption in C57BL/6J mice.

引用

页码：668 / 672

页数：5

共 19 条

[1] REDUCED LEUCINE-ENKEPHALIN LIKE IMMUNOREACTIVE SUBSTANCE IN HAMSTER BASAL GANGLIA AFTER LONG-TERM ETHANOL EXPOSURE [J].