POLYMORPHISM IN HUMAN IL-1 RECEPTOR ANTAGONIST GENE INTRON-2 IS CAUSED BY VARIABLE NUMBERS OF AN 86-BP TANDEM REPEAT

被引：53

作者：

TARLOW, JK

BLAKEMORE, AIF

LENNARD, A

SOLARI, R

HUGHES, HN

STEINKASSERER, A

DUFF, GW

机构：

[1] UNIV SHEFFIELD,ROYAL HALLAMSHIRE HOSP,DEPT MED,MOLEC MED SECT,SHEFFIELD S10 2JF,S YORKSHIRE,ENGLAND

[2] YAMANOUCHI RES INST,OXFORD,ENGLAND

[3] MANCHESTER METROPOLITAN UNIV,DEPT BIOL SCI,MANCHESTER,ENGLAND

[4] UNIV OXFORD,DEPT BIOCHEM,MRC,IMMUNOCHEM UNIT,OXFORD,ENGLAND

来源：

HUMAN GENETICS | 1993年 / 91卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We have investigated the polymorphism in intron 2 of the interleukin-1 receptor antagonist gene and identified two new alleles of the system. We have shown that the polymorphism is caused by the variable copy number of an 86-bp sequence, by using the polymerase chain reaction and primers immediately flanking the repeat region, and by direct sequencing. The repeat region contains three potential protein-binding sites and therefore the variable copy number may have functional significance.

引用

页码：403 / 404

页数：2

共 5 条

[1] BLOCKING IL-1 - INTERLEUKIN-1 RECEPTOR ANTAGONIST INVIVO AND INVITRO [J].