FETAL HEPATOSPLENOMEGALY ASSOCIATED WITH TRANSIENT MYELOPROLIFERATIVE DISORDER IN TRISOMY-21

被引:24
作者
MACONES, GA [1 ]
JOHNSON, A [1 ]
TILLEY, D [1 ]
WADE, R [1 ]
WAPNER, R [1 ]
机构
[1] JEFFERSON MED COLL,DEPT OBSTET & GYNECOL,DIV MATERNAL FETAL MED,PHILADELPHIA,PA
关键词
DOWN SYNDROME; HEPATOSPLENOMEGALY;
D O I
10.1159/000264219
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The in utero diagnosis of fetal myeloproliferative disease was made by cordocentesis following the ultrasound appearance of fetal hepatosplenomegaly and mild hydrops. The 2 fetuses reported both had leukocyte counts greater than 75,000/mm(3) with a predominance of blast forms. In both cases the karyotype revealed trisomy 21.
引用
收藏
页码:131 / 133
页数:3
相关论文
共 7 条
[1]  
Miller R.W., Persons at exceptionally high risk of leukemia, Cancer Res, 27, pp. 2420-2423, (1967)
[2]  
Krivit W., Good R.A., Simultaneous occurrence of mongolism and leukemia: Report of a nationwide survey, Am J Dis Child, 99, pp. 289-298, (1957)
[3]  
Ragab A.H., Abdel-Mageed A., Shaster J.J., Frankel L.S., Pullen J., van Eys J., Sullivan M.P., Boyett J., Borowtiz M., Christ W.M., Clinical characteristics and treatment outcome of children with acute lymphocytic leukemia and Down's syndrome, Cancer, 67, pp. 1057-1063, (1991)
[4]  
Wong K.Y., Jones M.M., Srivastava A.K., Gruppo R.A., Transient myeloproliferative disorder and acute non-lymphoblastic leukemia in Down syndrome, J Pediatr, 112, pp. 18-22, (1988)
[5]  
Hayashi Y., Eguchi M., Sugita S., Nakazawa S., Sato T., Kojima S., Bessho F., Konishi S., Inaba T., Hanada R., Yamamoto K., Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down syndrome, Blood, 72, pp. 15-23, (1988)
[6]  
Coulombel L., Derycke M., Villeval J.L., Leonard C., Breton-Gorius J., Vial M., Bourgeois P., Tchernia G., Characterization of the blast cell population in two neonates with Down syndrome and transient myeloproliferative disorder, Br J Haemat, 66, pp. 69-87, (1987)
[7]  
DeAlarcon P.A., Patil S., Goldberg J., Allen J.B., Shaw S., Infants with Down syndrome: Use of cytogenetic studies and in-vitro colony assay for granulocyte progenitor to distinguish acute non-lymphocytic leukemia from a transient myeloproliferative disorder, Cancer, 60, pp. 987-993, (1987)