NEOADJUVANT HORMONAL-THERAPY BEFORE RADICAL PROSTATECTOMY DECREASES THE NUMBER OF POSITIVE SURGICAL MARGINS IN STAGE T2 PROSTATE-CANCER - INTERIM RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL

被引：156

作者：

VANPOPPEL, H

DERIDDER, D

ELGAMAL, AA

VANDEVOORDE, W

WERBROUCK, P

ACKAERT, K

OYEN, R

PITTOMVILS, G

BAERT, L

ASSENMACHER, C

BILLIET, I

HARDEMAN, M

MATTELAER, J

BOECKX, G

CASSELMAN, J

DEBRUYNE, R

DHOEDT, M

DELAERE, K

LEONARD, A

MORTELMANS, B

VALCKE, A

RENDERS, G

VANHOUCKE, JL

VANOYEN, P

机构：

[1] KATHOLIEKE UNIV LEUVEN, DEPT PATHOL, B-3001 LOUVAIN, BELGIUM

[2] KATHOLIEKE UNIV LEUVEN, DEPT RADIOL, B-3001 LOUVAIN, BELGIUM

[3] KATHOLIEKE UNIV LEUVEN, DEPT PHYS, B-3001 LOUVAIN, BELGIUM

[4] KLIN MARIA VOORZIENIGHEID, DEPT UROL, KORTRIJK, BELGIUM

[5] KLIN ST ELISABETH, DEPT UROL, TURNHOUT, BELGIUM

来源：

JOURNAL OF UROLOGY | 1995年 / 154卷 / 02期

关键词：

PROSTATECTOMY; PROSTATIC NEOPLASMS; HORMONES; CARCINOMA;

D O I：

10.1016/S0022-5347(01)67068-X

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: We investigated the effect of neoadjuvant treatment before radical prostatectomy for clinically localized prostate cancer. Materials and Methods: A total of 130 patients with stages T2b and T3 prostate cancer was randomized in a multicenter study: 62 underwent immediate radical prostatectomy and 65 received 560 mg, estramustine phosphate daily for 6 weeks preoperatively. Results: For clinical stage T2b tumors the neoadjuvant treatment resulted in a significant decrease in positive surgical margins compared to the nonpretreated group. This difference was not found for clinical stage T3 tumors. The impact on progression and survival still must be analyzed. Conclusions: Neoadjuvant treatment can be beneficial for clinical stage T2 prostate cancer. Optimal treatment for stage T3 tumors remains controversial.

引用

页码：429 / 434

页数：6

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