CHANGING CYTOGENETIC PICTURE IN AN ACUTE MYELOPROLIFERATIVE DISORDER

Described herein is a case of acute myeloproliferative disorder in which the presenting pancytopenic picture was associated with multiple chromosomal abnormalities including a major hypodiploid line, a ring form, aneuploidy, polyploidy and fragmentation. The overt leukemic phase which occurred three and a half months later was preceded and accompanied by an additional hyperdiploid line. The close relationship between the chromosomal change and clinical course suggests that repeated cytogenetic studies in this type of patient may be useful from the prognostic and therapeutic point of view. © 1969.