PREDICTED SECONDARY STRUCTURE OF CALCITONIN IN RELATION TO THE BIOLOGICAL-ACTIVITY

被引：26

作者：

MERLE, M

LEFEVRE, G

MILHAUD, G

机构：

[1] Laboratoire Associé 163, C.N.R.S., C.H.U. Saint-Antoine, 75012 Paris, 27, rue de Chaligny

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91817-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The secondary structure of the natural analogues of calcitonin have been predicted using the methods of Burgess et al., Chou and Fasman, and Lim. The predicted structures were similar in the N-terminal part of the chain, but were variable in other regions of the molecules. The higher hypocalcaemic potency of ultimobranchial calcitonins as compared to thyroidal calcitonins may be related to the higher potential for helical structure in the former. © 1979.

引用

页码：455 / 460

页数：6

共 20 条

[1]

[Anonymous], 1978, ATLAS PROTEIN SEQ ST

[2]

BREWER HB, 1970, J BIOL CHEM, V245, P2402

[3]

BURGESS AW, 1974, ISRAEL J CHEM, V12, P239

[4] CONFORMATIONAL PARAMETERS FOR AMINO-ACIDS IN HELICAL, BETA-SHEET, AND RANDOM COIL REGIONS CALCULATED FROM PROTEINS [J].