EFFECT OF STARVATION ON THE RATE OF PROTEIN-SYNTHESIS IN RAT-LIVER AND SMALL-INTESTINE

被引：398

作者：

MCNURLAN, MA

TOMKINS, AM

GARLICK, PJ

机构：

来源：

BIOCHEMICAL JOURNAL | 1979年 / 178卷 / 02期

关键词：

D O I：

10.1042/bj1780373

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A method is described that allows for measurement of protein synthesis in liver and intestine in the rat. By injecting a massive amount of [14C]leucine (100 μmol/100g body wt.) an attempt has been made to overcome problems of precursor specific radioactivity and problems arising from the breakdown of labelled protein that are encountered when tracer amounts of amino acids are used. Starvation for 2 days resulted in a decline in the rate of total liver protein synthesis from 87%/day to 62%/day. In jejunal mucosa the rate of protein synthesis was 136%/day. This declined to 105%/day after 2 days of starvation.

引用

页码：373 / 379

页数：7

共 30 条

[1]

ALPERS DH, 1973, GASTROENTEROLOGY, V64, P471

[2] PROTEIN-SYNTHESIS IN INTESTINAL-MUCOSA - EFFECT OF ROUTE OF ADMINISTRATION OF PRECURSOR AMINO-ACIDS [J].