EXPERIMENTAL INHIBITION OF PEROXISOMAL BETA-OXIDATION IN RATS - INFLUENCE ON BRAIN MYELINATION

被引：16

作者：

VANDENBRANDEN, C ^{[1
]}

LEEMAN, J ^{[1
]}

DACREMONT, G ^{[1
]}

COLLUMBIEN, R ^{[1
]}

ROELS, F ^{[1
]}

机构：

[1] STATE UNIV GHENT,KLIN KINDERZIEKTEN C HOOFT,B-9000 GHENT,BELGIUM

来源：

GLIA | 1990年 / 3卷 / 06期

关键词：

Commissura anterior; Corpus callosum; Glial nuclei; Metabolic disease; Texture parameters; VLCFA;

D O I：

10.1002/glia.440030604

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Oral administration of thioridazine, an inhibitor of peroxisomal β‐oxidation, to normal rats from weaning till day 60 causes a small increase of the very long chain fatty acid C26 in brain lipids. Myelination in the brain is decreased. In the genu of the corpus callosum the ratio of non‐myelinated/myelinated axons is increased. In the commissura anterior the myelin sheaths of the axons are significantly thinner in treated than in control animals. Undernourishment caused by the drug is minimal in this experiment. Area and total DNA of glial nuclei are unaltered in both the genu and the commissura anterior of treated rats. The distribution of chromatin (texture), however, shows small differences in the corpus callosum. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：458 / 463

页数：6

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