GONADAL-HORMONES AFFECT THE HYPOTHERMIA INDUCED BY SEROTONIN1A (5-HT1A) RECEPTOR ACTIVATION

被引：23

作者：

MATSUDA, T ^{[1
]}

NAKANO, Y ^{[1
]}

KANDA, T ^{[1
]}

IWATA, H ^{[1
]}

BABA, A ^{[1
]}

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,1-6 YAMADAOKA,SUITA,OSAKA 565,JAPAN

来源：

LIFE SCIENCES | 1991年 / 48卷 / 17期

关键词：

D O I：

10.1016/0024-3205(91)90122-R

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Subcutaneous injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in mice caused hypothermia which was antagonized by pindolol. The hypothermic effect of 8-OH-DPAT was pronounced in female than in male mice. The sex difference in the hypothermic effect was also observed after pretreatment with proadifen. The hypothermic effect of 8-OH-DPAT was attenuated by ovariectomy. In the ovariectomized mice, the effect of 8-OH-DPAT on rectal temperature was enhanced by chronic estradiol and the enhancement was blocked by simultaneous administration of testosterone. In male mice the hypothermic effect of 8-OH-DPAT was enhanced by castration. These results suggest that gonadal hormones affect the 5-HT1A receptor-mediated response.

引用

页码：1627 / 1632

页数：6

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