INFANTILE STIMULATION AND THE ROLE OF THE BENZODIAZEPINE RECEPTOR SYSTEM IN ADULT ACQUISITION OF 2-WAY AVOIDANCE-BEHAVIOR

被引：19

作者：

ESCORIHUELA, RM ^{[1
]}

FERNANDEZTERUEL, A ^{[1
]}

NUNEZ, FJ ^{[1
]}

ZAPATA, A ^{[1
]}

TOBENA, A ^{[1
]}

机构：

[1] AUTONOMOUS UNIV BARCELONA,SCH MED,DEPT PSYCHIAT,E-08193 BARCELONA,SPAIN

来源：

PSYCHOPHARMACOLOGY | 1992年 / 106卷 / 02期

关键词：

POSTNATAL EXPERIENCE; HANDLING; RO; 15-1788; COPING BEHAVIOR; EMOTIONAL REACTIVITY; RAT;

D O I：

10.1007/BF02801985

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study shows that postnatal "consistent" handling (CH) of rats had long-lasting improving effects on coping with an stressful task (i.e. two-way active avoidance), and that such effects were partially prevented by acute Ro 15-1788 (antagonist of benzodiazepine receptor-BZR; 5 mg/kg) administration. Long-lasting detrimental effects in the same task were also observed in rats which received postnatal "inconsistent" handling (INCH), effects that were slightly increased by acute Ro 15-1788 treatment. Finally, Ro 15-1788 tended to increase avoidance acquisition in non-handled (NH) animals. The observed effects of Ro 15-1788 could be partially attributed to a differential modulation of the process of avoidance acquisition depending on postnatal treatments producing different levels of emotionality.

引用

页码：282 / 284

页数：3

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