GALLIUM-67-LABELED LIPOSOMES WITH PROLONGED CIRCULATION - PREPARATION AND POTENTIAL AS NUCLEAR IMAGING AGENTS

被引：49

作者：

WOODLE, MC

机构：

[1] Liposome Technology Inc., Menlo Park, CA 94025

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 02期

关键词：

D O I：

10.1016/0969-8051(93)90107-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A method is described for Ga-67-labeling liposomes containing a polyethylene glycol coating which exhibit prolonged blood circulation, reduced liver and spleen uptake and accumulation in tumors. Applications as agents for diagnostic imaging and delivery of therapeutic agents are considered. Previous methods were adapted to compensate for the presence of low temperature phase transition phospholipids resulting in consistent loading with low levels of residual unentrapped label.

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页码：149 / 155

页数：7

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