A NEW, SEMIAUTOMATED SYSTEM FOR THE MICROSCALE SYNTHESIS OF PT-195M]CIS PLATIN SUITABLE FOR CLINICAL-STUDIES

被引：10

作者：

ANAND, D ^{[1
]}

WOLF, W ^{[1
]}

机构：

[1] UNIV SO CALIF,RADIOPHARM PROGRAM,LOS ANGELES,CA 90089

来源：

APPLIED RADIATION AND ISOTOPES | 1992年 / 43卷 / 06期

关键词：

D O I：

10.1016/0883-2889(92)90247-C

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A new, semi-automated system for the microscale synthesis of [Pt-195m]cis platin has been developed. Radiochemical yields of up to 70% of pure [Pt-195m]cis platin can be obtained routinely e.g. 555-629 MBq (15-17 mCi) from 925 MBq (25 mCi) of [Pt-195m]Pt metal. Chemical losses during synthesis, and radiation exposure of personnel, have been minimized. These increased yields are the consequence of the elimination of most transfers, and enhanced yields at most steps: ammination losses decreased from 27 to 7%, and at the diiodo- to di-acquo- conversion, from 34 to 11 %. The versatility of such a system is discussed.

引用

页码：809 / 814

页数：6

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