OVARIAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE - POTENTIAL PREDICTOR OF CONCEPTION BY IN-VITRO FERTILIZATION AND EMBRYO-TRANSFER

被引：64

作者：

MICHAEL, AE

GREGORY, L

WALKER, SM

ANTONIW, JW

SHAW, RW

EDWARDS, CRW

COOKE, BA

机构：

[1] ROYAL FREE HOSP,SCH MED,DEPT BIOCHEM,ROWLAND HILL ST,LONDON NW3 2PF,ENGLAND

[2] UNIV HOSP WALES,ACAD DEPT OBSTET & GYNAECOL,FERTIL UNIT,CARDIFF,WALES

[3] UNIV EDINBURGH,WESTERN GEN HOSP,DEPT MED,EDINBURGH EH8 9YL,MIDLOTHIAN,SCOTLAND

来源：

LANCET | 1993年 / 342卷 / 8873期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0140-6736(93)91710-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cortisol is converted to the inactive glucocorticoid, cortisone, in several tissues by 11beta-hydroxysteroid dehydrogenase (11betaHSD). We have recently measured 11betaHSD activity in cultured human granulosa-lutein cells recovered from patients undergoing in-vitro fertilisation and embryo transfer (IVF-ET). We now report an association between the outcome of IVF-ET and 11betaHSD activity in these cells. Of the 64 patients studied, 32 had detectable 11betaHSD activity and none became pregnant; whereas 76% of the remaining ''11betaHSD-negative'' patients achieved pregnancies. Hence 11betaHSD activity may predict the outcome of IVF-ET.

引用

页码：711 / 712

页数：2

共 7 条

[1] LEVELS OF STEROID-BINDING PROTEINS AND STEROIDS IN HUMAN PREOVULATORY FOLLICLE FLUID AND SERUM AS PREDICTORS OF SUCCESS IN INVITRO FERTILIZATION-EMBRYO TRANSFER TREATMENT [J].